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The Positron Emission Tomography (PET) based on the coincident registration of the annihilation photons from the positron decay mode has gained important clinical relevance, especially in oncology. The combined functional (PET) and morphological (CT) imaging modalities in one instrument (PET-CT) is today a standard tool in nuclear medical diagnosis. Based on own experiences the author will give in this presentation an overview focusing with selected examples on different production modes for radioisotopes with small and medium cyclotrons and explain some aspects of the targetry for gases, liquids and solids.