General Seminars

Cell cycle checkpoints and DNA repair after radiation

by Randi Syljuåsen (Institute for Cancer Research, Norway)

Training and Research Centre of IFIN-HH

Training and Research Centre of IFIN-HH

In clinical radiotherapy the cancer cells are killed largely due to DNA
double strand breaks caused by ionizing radiation. However, in some cases
the tumor cells may survive the damage due to efficient DNA repair. One
promising strategy to improve treatment of radioresistant tumors is
therefore to combine radiotherapy with inhibitors of DNA repair. Here, I
will discuss how cell cycle checkpoints contribute to DNA repair and tumor
radioresistance. I will also present a large-scale screen aimed at
identifying drugs that inhibit DNA repair after radiation. Finally, I will
discuss possible differences between X-ray and proton irradiation in this